What are stem cells?

Stem cells are already naturally a part of human repairing system, and they are predecessors of all cells in our body. They are non-specialized and can become exactly the same as the cells of certain tissues and organs – they are the only cells of a human organism that have the ability to differentiate into different tissue-specific cells.

Medicine today uses this ability to achieve the reparation of tissues and organs, as a part of many degenerative systemic diseases, reversing the damage made in the organism. Stem cells replace, regrow, rejuvenate and repair on a cellular level, they are the building blocks from which all healing of the body stems.

The usage of stem cells in medicine

Stem cell therapy is an intervention strategy which introduces new adult stem cells into damaged tissue in order to treat a disease or injury. A stem cell is essentially the building block of the human body.

Unlike a regular cell, which can only replicate to create more of its own kind of cells, a stem cell can make any one of the 220 different cells in the human body. Stem cells are one of the most powerful discoveries of the modern medicine which are able to change how we see the treatment of many diseases and give people health, youth, strength, longevity or even the last chance to live. Impressive performance and capabilities of these cells can make your immune system and metabolic state stable and make you resistant to pathological agents from the environment which would in combination with stress make your body susceptible to many diseases. Once stem cells are enriched and their number enlarged during the treatment, they improve both symptoms of the disease and overall health. Stem cells have a unique capability to find a damaged area inside an organism and repair it.

The usage of stem cells in medicine

Stem cell therapy is an intervention strategy which introduces new adult stem cells into damaged tissue in order to treat a disease or injury. A stem cell is essentially the building block of the human body.

Unlike a regular cell, which can only replicate to create more of its own kind of cells, a stem cell can make any one of the 220 different cells in the human body. Stem cells are one of the most powerful discoveries of the modern medicine which are able to change how we see the treatment of many diseases and give people health, youth, strength, longevity or even the last chance to live. Impressive performance and capabilities of these cells can make your immune system and metabolic state stable and make you resistant to pathological agents from the environment which would in combination with stress make your body susceptible to many diseases. Once stem cells are enriched and their number enlarged during the treatment, they improve both symptoms of the disease and overall health. Stem cells have a unique capability to find a damaged area inside an organism and repair it.

What Results Can You Expect?

Stem cell treatments can be used and combined here at IM Clinic. We successfully treat sports injuries, allergies and sinusitis, hepatitis, as well as osteoporosis, diabetes, sexual dysfunction. Stem cell treatment can also be used for anti-aging procedures. IM Clinic provides treatments which rejuvenate your face, body, organs and increase your general well-being.

Types of stem cells

There are two types of stem cells which can be used in a stem cell treatment:

Autologous – from patient’s own body (Bone marrow, Adipose tissue stem cells).
Allogenic – donor stem cells.

What is the process?

The whole treatment can be described in 4 simple steps:

1) Harvesting your own stem cells from your fat
2) Separation of stem cells from fat
3) Activation of stem cells
4) Inserting stem cells through infusion

Stem cell treatments can be used and combined here at IM Clinic. We successfully treat sports injuries, allergies and sinusitis, hepatitis, as well as osteoporosis, diabetes, sexual dysfunction. Stem cell treatment can also be used for anti-aging procedures. IM Clinic provides treatments which rejuvenate your face, body, organs and increase your general well-being.

Types of stem cells

There are two types of stem cells which can be used in a stem cell treatment:

Autologous – from patient’s own body (Bone marrow, Adipose tissue stem cells).
Allogenic – donor stem cells.

What is the process?

The whole treatment can be described in 4 simple steps:

1) Harvesting your own stem cells from your fat
2) Separation of stem cells from fat
3) Activation of stem cells
4) Inserting stem cells through infusion

IM Clinic process

Stem cell therapy is an intervention strategy which introduces new adult stem cells into damaged tissue in order to treat a disease or injury. A stem cell is essentially the building block of the human body.

IM Clinic specialize in Autologous, bone marrow and adipose tissue-derived stem cells which are extracted from lower abdominal area of patient’s own body. The whole process is quick, non-invasive and effective, done under local anesthesia and combined with intravenous sedation, so our patients can avoid all risks associated with general anesthesia and intubation. With modern, specialized equipment used by the experienced stem cell specialist team, these procedures are technically easy to perform.

Iliac bone is only 1- 2 cm under the skin, so by using clear anatomical orienteers, the needle aspiration of bone marrow is done in approximately 15 minutes.

The most commonly-used cells are adipose-derived stem cells, located in the patient’s fat, so they can be easily extracted from the lower abdominal area through a simple process of mini-liposuction. The patient is awake after the process of harvesting, and because the whole process is done using only a needle, the surrounding tissue trauma is minimal.

The main advantage in both cases (bone marrow and adipose tissue stem cells) is the lack of risk of immune rejection of the therapy, as well as disease transmission. The whole process can be done in one single day!

IM Clinic process

Stem cell therapy is an intervention strategy which introduces new adult stem cells into damaged tissue in order to treat a disease or injury. A stem cell is essentially the building block of the human body.

IM Clinic specialize in Autologous, bone marrow and adipose tissue-derived stem cells which are extracted from lower abdominal area of patient’s own body. The whole process is quick, non-invasive and effective, done under local anesthesia and combined with intravenous sedation, so our patients can avoid all risks associated with general anesthesia and intubation. With modern, specialized equipment used by the experienced stem cell specialist team, these procedures are technically easy to perform.

Iliac bone is only 1- 2 cm under the skin, so by using clear anatomical orienteers, the needle aspiration of bone marrow is done in approximately 15 minutes.

The most commonly-used cells are adipose-derived stem cells, located in the patient’s fat, so they can be easily extracted from the lower abdominal area through a simple process of mini-liposuction. The patient is awake after the process of harvesting, and because the whole process is done using only a needle, the surrounding tissue trauma is minimal.

The main advantage in both cases (bone marrow and adipose tissue stem cells) is the lack of risk of immune rejection of the therapy, as well as disease transmission. The whole process can be done in one single day!

Bone marrow stem cells

Bone-marrow-stem-cells
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It is hard to imagine modern regenerative medicine without the application of bone marrow stem cells. Conducting more than 1000 clinical studies in 100 000 patients, scientist have discovered that stem cells not only regenerate damaged or inactive cells, but also play additional roles. Namely, stem cells use special signal molecules, growth factors, interleukins to regulate and control the processes like inflammation, cellular metabolism and intercellular communication in the structure of tissues and organs.

Bone marrow stem cells are used in:

Sports medicine – the application of stem cells significantly reduces the recovery process after the rupture of the muscles and ligaments;
Orthopedics – The main indications for therapy are osteoarthritis, degenerative joint diseases, cartilage damage, which cause constant pain and also limit the movement and activity of the patient. Immediately after the first treatment, the pain intensity decreases and the mobility improves. After two to three months, by using magnetic resonance, the beginning of regeneration of the joint surface can be observed. It is necessary to repeat the procedure in a half a year to achieve a stable result. The application of stem cells and PRP enabled the percentage of operations (replacement of the joints) to be decreased by 62%.
Inflammatory conditions, such as rheumatoid arthritis, Crohn’s disease, ulcerative colitis, which are by their nature autoimmune diseases. Stem cell therapy often allows patients to enter stable remission and stop using corticosteroids and methotrexate.
Neurology, bone marrow stem cells help reduce hyperactivity in autism as well as spasticity in children’s cerebral palsy, including multiple sclerosis, as the result of a stroke.
Parkinson’s disease and dementia – the patient’s mental state improves, sleep normalizes, the confusion of consciousness and occurrence of hallucinations decrease.
Anti-aging, aesthetic medicine and cosmetology – By applying stem cell therapy to the skin of the face, the neck and the hand, the number and visibility of wrinkles are reduced, the size of undereye circles as well and skin is tighter. Hydration improves, and the effect of glowing skin is achieved.
Type 2 diabetes – stem cell administration helps with insulin resistance. It can also reduce the dose of the medication needed. In some cases, a patient can stop using medicaments altogether.

Stem cell treatment reduces systemic inflammation, caused by diabetes. This type of inflammation usually leads to a shortening of life expectancy of people with this disease.

– The therapy’s positive effect on the on blood vessels and nerves increases sensitivity (feelings of tingling, chewing, discomfort in the feet, legs are neutralized); the vision improves, the patient can feel the new life energy. There is no need to rest during the day.

– This therapeutic treatment also significantly improves libido and erectile function.

Bone marrow stem cells

Bone-marrow-stem-cells
play-button-1

It is hard to imagine modern regenerative medicine without the application of bone marrow stem cells. Conducting more than 1000 clinical studies in 100 000 patients, scientist have discovered that stem cells not only regenerate damaged or inactive cells, but also play additional roles. Namely, stem cells use special signal molecules, growth factors, interleukins to regulate and control the processes like inflammation, cellular metabolism and intercellular communication in the structure of tissues and organs.

Bone marrow stem cells are used in:

Sports medicine – the application of stem cells significantly reduces the recovery process after the rupture of the muscles and ligaments;
Orthopedics – The main indications for therapy are osteoarthritis, degenerative joint diseases, cartilage damage, which cause constant pain and also limit the movement and activity of the patient. Immediately after the first treatment, the pain intensity decreases and the mobility improves. After two to three months, by using magnetic resonance, the beginning of regeneration of the joint surface can be observed. It is necessary to repeat the procedure in a half a year to achieve a stable result. The application of stem cells and PRP enabled the percentage of operations (replacement of the joints) to be decreased by 62%.
Inflammatory conditions, such as rheumatoid arthritis, Crohn’s disease, ulcerative colitis, which are by their nature autoimmune diseases. Stem cell therapy often allows patients to enter stable remission and stop using corticosteroids and methotrexate.
Neurology, bone marrow stem cells help reduce hyperactivity in autism as well as spasticity in children’s cerebral palsy, including multiple sclerosis, as the result of a stroke.
Parkinson’s disease and dementia – the patient’s mental state improves, sleep normalizes, the confusion of consciousness and occurrence of hallucinations decrease.
Anti-aging, aesthetic medicine and cosmetology – By applying stem cell therapy to the skin of the face, the neck and the hand, the number and visibility of wrinkles are reduced, the size of undereye circles as well and skin is tighter. Hydration improves, and the effect of glowing skin is achieved.
Type 2 diabetes – stem cell administration helps with insulin resistance. It can also reduce the dose of the medication needed. In some cases, a patient can stop using medicaments altogether.

Stem cell treatment reduces systemic inflammation, caused by diabetes. This type of inflammation usually leads to a shortening of life expectancy of people with this disease.

– The therapy’s positive effect on the on blood vessels and nerves increases sensitivity (feelings of tingling, chewing, discomfort in the feet, legs are neutralized); the vision improves, the patient can feel the new life energy. There is no need to rest during the day.

– This therapeutic treatment also significantly improves libido and erectile function.

Adipose stem cells

Adipose-stem-cells
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There is an ongoing controversy regarding the application of adipose stem cells. There is a myriad of documented positive effects when using stem cells in various medical treatments. This is especially true in situations when neither medicament therapy nor surgical approach has been successful. On the other hand, the use of stem cells is being associated with serious medical risks such as cancer and the occurrence of genetic mutations.

As it generally is the case, the truth is somewhere in the middle. The science and medicine have acquired the skills which help isolate particular types of stem cells, but are still unable to completely control their activity; those are embryonic (fetal) cells and IPS cells (induced pluripotent cells). These cells can grow and differentiate to give any type of tissue, but are not safe to use. Therefore, their application for medical purposes is strictly forbidden. Other cell types, which are effectively applied in medicine, have been well researched and their safety has been repeatedly confirmed. These are some examples:
• Hematopoietic stem cells give rise to blood cells. They are present in bone marrow and also in blood. The body uses them to produce erythrocytes, thrombocytes, leukocytes and the cells of the immune system. The transplantation of these cell types in hematology has virtually replaced a bone marrow transplant.
• Mesenchymal stromal cells are harvested from different body regions (adipose tissue, skin, dental gum tissue, bone marrow). These cells have the ability to divide and differentiate and are considered adult stem cells. They are widely and successfully used in orthopedics, sports medicine, as well as treating burns and in reconstructive surgeries.

The procedure for harvesting stem cells consists of several stages:

Extracting material. This part is done in local anesthesia or in sedation; the special tumescent Klein solution is introduced under the skin. The application leads to the swelling of the adipose tissue and the constriction of blood vessels, and it ensures that the procedure goes smoothly. After 15-20 minutes, a trained specialist uses a thin cannula with a special technique to gently collect approximately 150 ml of adipose tissue under sterile conditions.

Processing. In a laboratory, a biologist purifies adipose tissue and starts the process of extracting a special fraction from the SVF sample (stromal vascular fraction). In order to isolate the tissue, a special method which uses an enzyme collagenase is used. SVF fraction can be extracted from the rest of the fraction in three hours. An SVF fraction consists of a special mix of cells which have a good regenerative potential. Among cells in this fraction, there are progenitor cells, preadipocytes (the cells that give rise to adipose cells), endothelial cells, fibroblasts, mesenchymal stem cells. SVF can be used as a standalone cell product.

Forming of the culture of mesenchymal stem cells derived from adipose tissue. The cells obtained in the previous stage, are cultivated in special bottles or cellular fabrics. The walls of the bottles and the MSC membranes have adhesive properties, so MSC cells can bond to walls. Other cell types remain in the liquid cellular layer and are removed when the nutritive medium in which the cells are cultivated is replaced. Under the conditions that allow for cells to divide (temperature, the optimal composition of gases, the presence of certain microelements in nutritive medium), the forming of cell culture begins. The process takes between 6 to 8 weeks and provides 10 therapeutic doses (100-150 million cells per dosage). All cells are tested for sterility, non-pyrogenicity, imunophenotypization, and genome stability.

Application of cells. Depending on the indications, the methods of applying cells can vary. When treating joints and ligaments, the cells can be introduced by using ultrasound or fluoroscopic navigation, and in that case, the cells are introduced into the joint. In chronical conditions of the respiratory system, we use the inhalation method. In certain neurological conditions, we use the intrathecal and intranasal application of cells.

Adipose stem cells

Adipose-stem-cells
play-button-1

There is an ongoing controversy regarding the application of adipose stem cells. There is a myriad of documented positive effects when using stem cells in various medical treatments. This is especially true in situations when neither medicament therapy nor surgical approach has been successful. On the other hand, the use of stem cells is being associated with serious medical risks such as cancer and the occurrence of genetic mutations.

As it generally is the case, the truth is somewhere in the middle. The science and medicine have acquired the skills which help isolate particular types of stem cells, but are still unable to completely control their activity; those are embryonic (fetal) cells and IPS cells (induced pluripotent cells). These cells can grow and differentiate to give any type of tissue, but are not safe to use. Therefore, their application for medical purposes is strictly forbidden. Other cell types, which are effectively applied in medicine, have been well researched and their safety has been repeatedly confirmed. These are some examples:
• Hematopoietic stem cells give rise to blood cells. They are present in bone marrow and also in blood. The body uses them to produce erythrocytes, thrombocytes, leukocytes and the cells of the immune system. The transplantation of these cell types in hematology has virtually replaced a bone marrow transplant.
• Mesenchymal stromal cells are harvested from different body regions (adipose tissue, skin, dental gum tissue, bone marrow). These cells have the ability to divide and differentiate and are considered adult stem cells. They are widely and successfully used in orthopedics, sports medicine, as well as treating burns and in reconstructive surgeries.

The procedure for harvesting stem cells consists of several stages:

Extracting material. This part is done in local anesthesia or in sedation; the special tumescent Klein solution is introduced under the skin. The application leads to the swelling of the adipose tissue and the constriction of blood vessels, and it ensures that the procedure goes smoothly. After 15-20 minutes, a trained specialist uses a thin cannula with a special technique to gently collect approximately 150 ml of adipose tissue under sterile conditions.

Processing. In a laboratory, a biologist purifies adipose tissue and starts the process of extracting a special fraction from the SVF sample (stromal vascular fraction). In order to isolate the tissue, a special method which uses an enzyme collagenase is used. SVF fraction can be extracted from the rest of the fraction in three hours. An SVF fraction consists of a special mix of cells which have a good regenerative potential. Among cells in this fraction, there are progenitor cells, preadipocytes (the cells that give rise to adipose cells), endothelial cells, fibroblasts, mesenchymal stem cells. SVF can be used as a standalone cell product.

Forming of the culture of mesenchymal stem cells derived from adipose tissue. The cells obtained in the previous stage, are cultivated in special bottles or cellular fabrics. The walls of the bottles and the MSC membranes have adhesive properties, so MSC cells can bond to walls. Other cell types remain in the liquid cellular layer and are removed when the nutritive medium in which the cells are cultivated is replaced. Under the conditions that allow for cells to divide (temperature, the optimal composition of gases, the presence of certain microelements in nutritive medium), the forming of cell culture begins. The process takes between 6 to 8 weeks and provides 10 therapeutic doses (100-150 million cells per dosage). All cells are tested for sterility, non-pyrogenicity, imunophenotypization, and genome stability.

Application of cells. Depending on the indications, the methods of applying cells can vary. When treating joints and ligaments, the cells can be introduced by using ultrasound or fluoroscopic navigation, and in that case, the cells are introduced into the joint. In chronical conditions of the respiratory system, we use the inhalation method. In certain neurological conditions, we use the intrathecal and intranasal application of cells.

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